Título

CHORIOCAPILLARIS AND RETINAL VASCULAR PLEXUS DENSITY OF DIABETIC EYES USING SPLIT-SPECTRUM AMPLITUDE DECORRELATION SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Introdução

Split-spectrum amplitude decorrelation angiography (SSADA) for spectral domain optical coherence tomography (SD-OCT) has enabled detailed, non-invasive assessment of vascular flow. This study evaluates choriocapillaris and retinal capillary perfusion density (CPD) in diabetic eyes using OCT angiography (OCTA).

Métodos

Records of 113eyes that underwent OCTA imaging at a single institution were reviewed. Eyes were grouped as non-diabetic controls (37 eyes), patients with diabetes mellitus (DM) without diabetic retinopathy (DM without DR, 31 eyes), non-proliferative diabetic retinopathy (NPDR, 41 eyes), and proliferative diabetic retinopathy (PDR, 26 eyes). Quantitative CPD analyses were performed on OCTA images for assessing perfusion density of the choriocapillaris and retinal plexus for all patients and compared between groups.

Resultados

Eyes with NPDR and PDR showed significantly decreased choriocapillaris CPD compared to controls, while DM eyes without DR did not show significant change. Choriocapillaris whole image CPD was decreased by 8.3% in eyes with NPDR (p

Conclusões

Choriocapillaris and retinal CPD are reduced in diabetic retinopathy, while foveal avascular zone area is increased in eyes with PDR. Vascular changes captured by new imaging modalities can further characterize diabetic choroidopathy. In conslusion, this study showed that OCTA is capable of detecting capillary perfusion changes in the retina and choriocapillaris of diabetic patients compared to healthy individuals as well as correlating these capillary density changes with the ocular disease severity.

Palavras Chave

diabetic, retinopathy, choroidopathy, Optical coherence tomography, angiography.

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