Título / Title

EVALUATION OF THE EFFECTIVENESS OF INTRAVITREAL OZURDEX IMPLANT IN REDUCING CENTRAL MACULAR THICKNESS IN PATIENTS WITH POST-SURGICAL MACULAR EDEMA

Introdução / Purpose

To demonstrate the effectiveness and safety of the intravitreal implant of Ozurdex in the treatment of post-surgical macular edema, in daily practice (real life scenario), based on a functional parameter - Visual acuity- and a structural parameter - Macular thickness documented by SD- OCT.

Material e Método / Methods

A comparative retrospective study of the cases treated from January 2020 to July 2021 was carried out.
Data analysis was based on the assessment of central macular thickness (mean thickness within the 1 mm circle of the ETDRS), as well as the mean total macular thickness including parafoveal and perifoveal regions.
The primary outcomes chosen were reduction in macular thickness on Cirrus SD-OCT and improvement in visual acuity. As a secondary outcome, we evaluated Complications associated with treatment: Increase in IOP, need for new intravitreal injection or surgical treatment, migration of Ozurdex to the previous chamber.

Resultados / Results

A statistically significant change was observed in the postoperative period when compared to the preoperative period for all parameters (p<0.001).
There is an effect of visual acuity at baseline, so that the worse the VA at baseline, the greater the improvement in the postoperative period.
There is a statistically significant effect of preoperative Central Macular Thickness and Central Average Thickness on the pre- and post-operative difference, so that the greater the thickness at baseline, the greater the difference observed after treatment.

Discussão e Conclusões / Conclusion

The analyzes of the variables show that there was functional and anatomical improvement after treatment of postsurgical macular edema with intravitreal Ozurdex implant.
There was a mean improvement in AV from 0.82 to 0.26 logMAR; Average CMT improvement from 460 to 341 microns and Average CMT improvement from 315 to 296 microns .
There was an impacting effect of preoperative values, so the worse the parameter at baseline, the greater the improvement after application

Palavras Chave

Ozurdex, Retina, Macular edema, post-surgical macular edema.

Area

CLINICAL RETINA