Título / Title

SAFETY OF INTRAVITREAL METOPROLOL IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY

Introdução / Purpose

To investigate ocular safety of intravitreal metoprolol in eyes with central serous chorioretinopathy.

Material e Método / Methods

Five eyes of five patients diagnosed with chronic central serous chorioretinopathy (cCSC) previously treated unsuccessfully with oral spirolactone, micropulse laser and intravitreal anti‐vascular endothelial growth factor agents were enrolled and received off-label intravitreal metoprolol (50µg/0.05 ml). Baseline and follow-up examinations included measurement of best-corrected visual acuity (BCVA), intraocular pressure, anterior chamber cellular/flare scores, vitritis classification, fluorescein and indocyanine green angiography, spectral domain optical coherence tomography and electroretinogaphy (ERG), recorded by means of DTL electrodes and following the standard suggested by the International Society for Clinical Electrophysiology of Vision (ISCEV). The total follow-up period was 4 weeks.

Resultados / Results

There was no significant differences between baseline and follow-up ERG parameters: scotopic or photopic, a- and b-wave amplitude and implicit time, nor oscillatory potentials amplitude, or whatsoever. No intraocular inflammation sign was observed. In addition, BCVA showed small improvement in 4 or kept baseline values in 1 patients. The subretinal and/or intraretinal fluid volume reduced in all patients at 1 month after treatment.

Discussão e Conclusões / Conclusion

Patients with refractory cCSC treated with intravitreal 50µg/0.05ml metoprolol showed no signs of acute ocular toxicity, along with intraretinal fluid reduction and slight BCVA improvement 1 month after injection. This data suggest that intravitreal metoprolol may be a safe alternative for cCSC.

Palavras Chave

intravitreal injection, β-blocker, metoprolol, ocular toxicity, electroretinogram, central serous chorioretinopathy.

Area

CLINICAL RETINA