Dados do Trabalho

Título

HEART RE-TRANSPLANTATION FOR CORONARY ALLOGRAFT VASCULOPATHY IN CHILDREN: 25 YEARS OF SINGLE-CENTRE EXPERIENCE

Introdução

Paediatric end-stage heart disease is surgically managed by heart transplantation. A major complication of primary transplantation (PTx) is coronary allograft vasculopathy (CAV), a form of accelerated atherosclerosis. Re-transplantation (RTx) has been the management of CAV, however there is limited comprehensive literature on this subject. Here we report 25 years of single-centre experience in managing CAV with RTx and place it in the context of recent studies.

Material e Método

A retrospective cohort study was undertaken on patients who underwent PTx

Resultados

Between 1992 and 2018, 200 children underwent heart transplantation. Ten re-transplantations were performed, for which seven (70%) were for CAV. Ages at RTx ranged from 11.5 to 29.3 years (19.1 ± 5.68 years; median 18.2 years). The mean time between PTx and RTx was 12.9 ± 3.4 years (median 13.4 years). Kaplan Meier survival rate was at one month, 3 years and 5 years was 85.7%, 71.5% and 47.6% respectively.

Discussão e Conclusões

Cardiac RTx can be a management option for CAV in patients who have undergone PTx in childhood with double immunosuppression therapy.

Palavras Chave

heart re-transplantation ; children; survival